Price comparison
Compounded tirzepatide vs compounded semaglutide: the price difference
Quick answer
Tirzepatide is the more expensive of the two almost everywhere. Of the 356 sellers that price both, tirzepatide costs more at 323, by a median of $81 a month. Across each whole market the median month is $272 for compounded tirzepatide and $199 for compounded semaglutide.
The two markets, side by side1
Every figure below is a true calendar month — what a seller bills, restated over 30.44 days — computed the same way on both indexes, so the two columns can be read against each other.
| Tirzepatide | Semaglutide | |
|---|---|---|
| Sellers tracked | 392 | 423 |
| With a computed monthly cost | 375 | 388 |
| Median month | $272 | $199 |
| Cheapest month | $61 | $54 |
The whole-market medians are a fair picture of the two prices, but they compare two different groups of companies. The sharper comparison is the one below: the same company, quoting both.
At the same seller2
356 sellers publish enough to compute a month on both molecules. At 323 of them tirzepatide costs more, at 14 the two cost the same to within a dollar, and at 19 tirzepatide is the cheaper of the two. These are the twenty cheapest for tirzepatide; each seller’s own page has its full working.
| Seller | Tirzepatide | Semaglutide | Difference |
|---|---|---|---|
| RxPepsDirect · entry price | $61 | $80 | −$19 |
| Collective | $86 | $76 | +$10 |
| PreventiveMD · entry price | $97 | $121 | −$23 |
| Teleios Health · entry price | $99 | $99 | $0 |
| Valhalla Vitality · entry price | $100 | $108 | −$7 |
| NextMeds | $109 | $79 | +$30 |
| Lean Meds | $109 | $79 | +$30 |
| Bayan Health | $119 | $129 | −$10 |
| MaxLife · entry price | $120 | $100 | +$20 |
| Embody | $129 | $79 | +$50 |
| BiltRx | $129 | $81 | +$48 |
| Ascend Medical · entry price | $130 | $122 | +$8 |
| OurView Health | $131 | $111 | +$20 |
| Fifty 410 · entry price | $133 | $199 | −$66 |
| Jyra Health | $133 | $169 | −$36 |
| FitFlow | $134 | $175 | −$41 |
| Cora Health | $135 | $175 | −$40 |
| EverSlim · entry price | $136 | $113 | +$23 |
| Fresh Day Meds · entry price | $140 | $140 | $0 |
| Stealth Health · entry price | $140 | $100 | +$40 |
“Entry price” marks a row where the seller’s figure holds at the starting dose only and rises as the dose does, so the difference in that row can change as you titrate. Semaglutide prices link to the seller’s page on Compounded Semaglutide, our sister index.
Where tirzepatide is the cheaper one1
It happens, and it is worth knowing where. At these sellers the tirzepatide month is lower than the semaglutide one:
- RxPepsDirect — $61 against $80, though the tirzepatide figure is an entry price that climbs with the dose.
- PreventiveMD — $97 against $121, though the tirzepatide figure is an entry price that climbs with the dose.
- Valhalla Vitality — $100 against $108, though the tirzepatide figure is an entry price that climbs with the dose.
- Bayan Health — $119 against $129.
- Fifty 410 — $133 against $199, though the tirzepatide figure is an entry price that climbs with the dose.
- Jyra Health — $133 against $169.
- FitFlow — $134 against $175.
- Cora Health — $135 against $175.
- GobyMeds — $145 against $169, though the tirzepatide figure is an entry price that climbs with the dose.
- FMmeds — $145 against $225.
- VevaRX — $156 against $189.
- HeliMeds — $162 against $260, though the tirzepatide figure is an entry price that climbs with the dose.
- Glam Health — $189 against $254.
- June Health — $202 against $283, though the tirzepatide figure is an entry price that climbs with the dose.
- Bloom MD — $253 against $275, though the tirzepatide figure is an entry price that climbs with the dose.
- Boston Medical Group — $253 against $325, though the tirzepatide figure is an entry price that climbs with the dose.
- Rebody Health — $272 against $326, though the tirzepatide figure is an entry price that climbs with the dose.
- Velvet Rx — $283 against $325.
- Aspen — $299 against $303.
Most of these are close, and several are entry prices. None of them changes the overall picture; what they change is the advice for one reader, which is to price the specific seller rather than the molecule.
What the difference buys3
The premium tracks the evidence. In SURMOUNT-5, the only randomized trial to put the two against each other in people with obesity and without diabetes, weight fell by 20.2% on tirzepatide and 13.7% on semaglutide over 72 weeks. That trial tested the approved products at their maximum tolerated doses, not any compounded vial — the full account, and what it could not answer, is on tirzepatide against semaglutide: the evidence.
So the honest framing is not “semaglutide is the cheap version.” They are different molecules: tirzepatide acts on two receptors and semaglutide on one — see how tirzepatide works — and a reader choosing between them is choosing a drug, not a discount.
Before switching to save money
A switch between molecules is a new prescription, not a price change. Neither approved label publishes a conversion between a tirzepatide dose and a semaglutide one, and semaglutide starts on its own low step and titrates up again — covered in switching sellers, or switching molecules. That is a decision for a prescriber, and it is not one a price index can make for you.
If the price is the problem, the first thing to compare is sellers of the same molecule: the spread inside the tirzepatide market is wider than the gap between the two molecules. Start with the cheapest tirzepatide at every dose, and if you do want the semaglutide side priced the same way, it is on Compounded Semaglutide, which the same people publish.
Questions
- Is compounded semaglutide cheaper than compounded tirzepatide?
- Usually. The median compounded semaglutide month is $199 against $272 for tirzepatide, and of the 356 sellers that price both, 323 charge more for tirzepatide.
- How much more does compounded tirzepatide cost than semaglutide?
- At the same seller, a median of $81 a month more, across 356 sellers that price both. The gap varies from seller to seller, and at 19 of them tirzepatide is the cheaper of the two.
- Can I switch from tirzepatide to semaglutide to save money?
- Only with a new prescription. They are different molecules, neither approved label publishes a dose conversion between them, and semaglutide is started at a low dose and titrated up again. That is a prescriber's decision, not a price decision.
- Does the extra cost of tirzepatide buy anything?
- In the one head-to-head trial in people with obesity and without diabetes, SURMOUNT-5, weight fell by 20.2% on tirzepatide and 13.7% on semaglutide over 72 weeks. That trial tested the approved products, not a compounded preparation.
Price information only. Nothing here is medical advice, and the cheaper molecule is not therefore the right one.
Sources
- This site's price index, computed from what sellers actually bill Read it
- Compounded Semaglutide, our sister index at compoundedsemaglutide.org — same publisher, same method
- SURMOUNT-5, New England Journal of Medicine 2025, as summarized on our research page