Price comparison
Compounded tirzepatide vs compounded semaglutide: the price difference
Quick answer
Tirzepatide is the more expensive of the two almost everywhere. Of the 354 sellers that price both, tirzepatide costs more at 333, by a median of $75 a month. Across each whole market the median month is $266 for compounded tirzepatide and $199 for compounded semaglutide.
The two markets, side by side1
Every figure below is a true calendar month — what a seller bills, restated over 30.44 days — computed the same way on both indexes, so the two columns can be read against each other.
| Tirzepatide | Semaglutide | |
|---|---|---|
| Sellers tracked | 384 | 410 |
| With a computed monthly cost | 362 | 378 |
| Median month | $266 | $199 |
| Cheapest month | $86 | $54 |
The whole-market medians are a fair picture of the two prices, but they compare two different groups of companies. The sharper comparison is the one below: the same company, quoting both.
At the same seller2
354 sellers publish enough to compute a month on both molecules. At 333 of them tirzepatide costs more, at 13 the two cost the same to within a dollar, and at 8 tirzepatide is the cheaper of the two. These are the twenty cheapest for tirzepatide; each seller’s own page has its full working.
| Seller | Tirzepatide | Semaglutide | Difference |
|---|---|---|---|
| Collective | $86 | $76 | +$10 |
| Teleios Health · entry price | $99 | $99 | $0 |
| Valhalla Vitality · entry price | $99 | $108 | −$9 |
| RxPepsDirect · entry price | $100 | $65 | +$36 |
| Mondae | $126 | $87 | +$39 |
| Eden | $129 | $99 | +$30 |
| NexLife | $129 | $109 | +$20 |
| OurView Health | $129 | $109 | +$20 |
| BiltRx | $129 | $81 | +$48 |
| NextMeds | $129 | $79 | +$50 |
| Lean Meds | $129 | $79 | +$50 |
| Ascend Medical · entry price | $130 | $122 | +$8 |
| CLYR Health · entry price | $136 | $169 | −$33 |
| PreventiveMD | $139 | $99 | +$40 |
| Stealth Health · entry price | $140 | $100 | +$40 |
| Embody | $140 | $86 | +$54 |
| Science & Co | $141 | $90 | +$51 |
| Healthicare | $144 | $126 | +$18 |
| GobyMeds · entry price | $145 | $169 | −$24 |
| Potere Health MD · entry price | $145 | $87 | +$58 |
“Entry price” marks a row where the seller’s figure holds at the starting dose only and rises as the dose does, so the difference in that row can change as you titrate. Semaglutide prices link to the seller’s page on Compounded Semaglutide, our sister index.
The gap between the two drugs is different at each seller. Among the sellers we work with, the Strut Health review records $151 a calendar month at the starting dose, the Belle Health review $249 a calendar month at every dose and the YourEra review $259 a calendar month at every dose. We may earn a commission from these sellers, and the full index orders every seller by price alone.
Where tirzepatide is the cheaper one1
It happens, and it is worth knowing where. At these sellers the tirzepatide month is lower than the semaglutide one:
- Valhalla Vitality — $99 against $108, though the tirzepatide figure is an entry price that climbs with the dose.
- CLYR Health — $136 against $169, though the tirzepatide figure is an entry price that climbs with the dose.
- GobyMeds — $145 against $169, though the tirzepatide figure is an entry price that climbs with the dose.
- HeliMeds — $162 against $245, though the tirzepatide figure is an entry price that climbs with the dose.
- June Health — $199 against $279, though the tirzepatide figure is an entry price that climbs with the dose.
- Believe Health — $222 against $253.
- Bloom MD — $244 against $270, though the tirzepatide figure is an entry price that climbs with the dose.
- Iron Med RX — $249 against $296.
Most of these are close, and several are entry prices. None of them changes the overall picture; what they change is the advice for one reader, which is to price the specific seller rather than the molecule.
How the approved drugs compared in a trial3
In the randomized SURMOUNT-5 trial of adults with obesity without type 2 diabetes, estimated weight loss at 72 weeks was 20.2% with tirzepatide and 13.7% with semaglutide. The head-to-head evidence covers the maximum tolerated doses of the approved injections. It cannot tell us whether a compounded preparation performs the same way or why sellers charge different prices.
So the honest framing is not “semaglutide is the cheap version.” They are different molecules: tirzepatide acts on two receptors and semaglutide on one — see how tirzepatide works — and a reader choosing between them is choosing a drug, not a discount.
Before switching to save money
A switch between molecules is a new prescription, not a price change. Neither approved label publishes a conversion between a tirzepatide dose and a semaglutide one, and semaglutide starts on its own low step and titrates up again — covered in switching sellers, or switching molecules. That is a decision for a prescriber, and it is not one a price index can make for you.
If the price is the problem, the first thing to compare is sellers of the same molecule: the spread inside the tirzepatide market is wider than the gap between the two molecules. Start with the cheapest tirzepatide at every dose to compare sellers on one basis. For semaglutide prices calculated the same way, use Compounded Semaglutide.
Questions
- Is compounded semaglutide cheaper than compounded tirzepatide?
- Usually. The median compounded semaglutide month is $199 against $266 for tirzepatide, and of the 354 sellers that price both, 333 charge more for tirzepatide.
- How much more does compounded tirzepatide cost than semaglutide?
- At the same seller, a median of $75 a month more, across 354 sellers that price both. The gap varies from seller to seller, and at 8 of them tirzepatide is the cheaper of the two.
- Can I switch from tirzepatide to semaglutide to save money?
- Only with a new prescription. They are different molecules, neither approved label publishes a dose conversion between them, and semaglutide is started at a low dose and titrated up again. That is a prescriber's decision, not a price decision.
- Does the extra cost of tirzepatide buy anything?
- In the one head-to-head trial in people with obesity and without diabetes, SURMOUNT-5, weight fell by 20.2% on tirzepatide and 13.7% on semaglutide over 72 weeks. That trial tested the approved products, not a compounded preparation.
Price information only. Nothing here is medical advice, and the cheaper molecule is not therefore the right one.
Sources
- This site's price index, computed from what sellers actually bill Read it
- Compounded Semaglutide, our sister index at compoundedsemaglutide.org — same publisher, same method
- Aronne LJ et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025. PMID 40353578 PubMed